Unbroken epidermal cysts, in addition, manifest arborizing telangiectasia, but ruptured ones showcase peripheral, linearly-arranged branched vessels (45). The dermoscopic presentation of steatocystoma multiplex, similar to milia, typically includes a peripheral brown border, linear vascular patterns, and a homogeneous yellow coloration of the involved area, as reported in reference (5). Notably, the linear vessels that define other cystic lesions discussed earlier are not representative of pilonidal cysts, which exhibit a different pattern involving dotted, glomerular, and hairpin-shaped vessels. Pink nodular lesions require a differential diagnosis that includes pilonidal cyst disease, amelanotic melanoma, basal cell carcinoma, squamous cell carcinoma, pyogenic granuloma, lymphoma, and pseudolymphoma in the assessment (3). Dermoscopic features frequently associated with pilonidal cyst disease, as per our cases and the two published cases, comprise a pink backdrop, central ulceration, peripherally arranged dotted vessels, and white linear patterns. Our observations highlight that pilonidal cyst disease's dermoscopic appearance includes central yellowish, structureless regions, accompanied by peripheral hairpin and glomerular vessels. In conclusion, dermoscopic features, as previously outlined, effectively separate pilonidal cysts from other skin lesions, thus aiding the diagnosis in patients where a pilonidal cyst is suspected clinically. To further delineate typical dermoscopic features and their rate of occurrence in this disease, prospective research is warranted.

Editor, I write to you concerning segmental Darier disease (DD), a condition of uncommon occurrence, with approximately 40 instances documented in the English-language medical literature. One proposed cause of the disease is a post-zygotic somatic mutation in the calcium ATPase pump, which is localized exclusively to lesional skin. Lesions in segmental DD type 1 are unilateral and follow Blaschko's lines, a pattern distinct from segmental DD type 2, which features concentrated areas of heightened severity in patients with generalized DD (1). The diagnosis of type 1 segmental DD is often challenging due to the absence of a positive family history, the delayed onset of the condition typically occurring in the third or fourth decade, and the absence of distinctive DD-related characteristics. Type 1 segmental DD's differential diagnosis encompasses acquired papular dermatoses arranged linearly or in a zosteriform pattern, including lichen planus, psoriasis, lichen striatus, and linear porokeratosis (2). We highlight two cases of segmental DD; the first, a 43-year-old female, displayed pruritic skin conditions for five years, with symptoms exacerbated by seasonal factors. Light brownish to reddish, keratotic small papules, arranged in a swirling pattern, were identified on the left abdomen and inframammary area during the examination (Figure 1a). A dermoscopic examination revealed yellowish-brown, polygonal or roundish areas, demarcated by a surrounding, whitish, featureless zone (Figure 1b). genetic screen Dermoscopic brownish polygonal or round areas, as observed, correlate histopathologically with hyperkeratosis, parakeratosis, and dyskeratotic keratinocytes, as evidenced by the biopsy specimen (Figure 1, c). Marked improvement was observed in the patient, as evidenced by Figure 1, panel d, after the administration of 0.1% tretinoin gel. On the right side of the upper abdomen of a 62-year-old woman, the second case exhibited a zosteriform arrangement of small red-brown papules, eroded papules, and yellowish crusts (Figure 2a). Surrounding structureless areas of whitish and reddish coloration encircled the polygonal, roundish, yellowish areas visualized in the dermoscopic image (Figure 2b). Orthokeratosis, compact in nature, was observed alongside small foci of parakeratosis. A significant granular layer, characterized by dyskeratotic keratinocytes, and areas of suprabasal acantholysis were further identified, leading to a diagnosis of DD (Figure 2, d, d). The patient experienced an improvement due to the application of topical steroid cream, in conjunction with 0.1% adapalene cream. Clinico-histopathologic correlation led to a final diagnosis of type 1 segmental DD in both cases; acantholytic dyskeratotic epidermal nevus, indistinguishable in both clinical and histological presentations from segmental DD, could not be excluded from the diagnosis solely based on the histopathological findings. The diagnosis of segmental DD was bolstered by the late emergence and worsening influenced by external factors, including heat, sunlight, and perspiration. Type 1 segmental DD is usually diagnosed through the combination of clinical and histopathological data, but dermoscopy effectively contributes to the diagnosis by eliminating potential alternatives and recognizing their unique dermoscopic characteristics.

While the urethra is not frequently a site of condyloma acuminatum, its appearance, if present, is generally concentrated near the distal end. A range of therapeutic strategies have been described for urethral condylomas. Extensive and variable therapies include laser treatment, electrosurgery, cryotherapy, and topical cytotoxic agents, exemplified by 80% trichloroacetic acid, 5-fluorouracil cream (5-FU), podophyllin, podophyllotoxin, and imiquimod. Intraurethral condylomata treatment frequently utilizes laser therapy as the preferred approach. A 25-year-old male patient presenting with meatal intraurethral warts was effectively treated using 5-FU after encountering treatment failures with laser therapy, electrosurgery, cryotherapy, imiquimod, and 80% trichloroacetic acid.

A diverse collection of skin conditions, ichthyoses, manifest with erythroderma and widespread scaling. The nature of the connection between ichthyosis and melanoma remains poorly understood. A unique case of acral melanoma on the palm is presented, arising in an elderly patient with the congenital condition of ichthyosis vulgaris. Ulceration accompanied the superficially spreading melanoma, as revealed by the biopsy. As far as we know, no acral melanomas have been observed in the population of patients with congenital ichthyosis. Undeniably, the probability of melanoma invasion and metastasis demands that patients diagnosed with ichthyosis vulgaris adhere to a schedule of regular clinical and dermatoscopic screenings.

In this case report, we examine a 55-year-old male patient exhibiting penile squamous cell carcinoma (SCC). tissue biomechanics The patient's penis housed a mass, incrementally expanding in size. To eliminate the mass, a partial penectomy was undertaken. Histopathological examination demonstrated a well-differentiated squamous cell carcinoma. Through the use of polymerase chain reaction, human papillomavirus (HPV) DNA was ascertained. The squamous cell carcinoma's HPV presence, identified as type 58, was confirmed through sequencing.

Skin and extracutaneous abnormalities frequently accompany each other, as commonly seen in a range of genetic syndromes. Despite the existing knowledge, unforeseen combinations of symptoms could still emerge. find more The Dermatology Department received a patient with multiple basal cell carcinomas, the source of which was a nevus sebaceous, a case report we present here. The patient's cutaneous malignancies were accompanied by palmoplantar keratoderma, prurigo nodularis, hypothyroidism, multiple lumbar abnormalities, a uterine myoma, an ovarian cyst, and a highly dysplastic colon adenoma. The co-occurrence of multiple conditions could potentially point to a genetic source for the diseases.

The inflammation of small blood vessels, a consequence of drug exposure, results in drug-induced vasculitis, potentially leading to damage in the affected tissue. Occasionally, chemotherapy or concomitant chemoradiotherapy has been linked to rare instances of drug-induced vasculitis, as noted in published medical reports. Stage IIIA small cell lung cancer (SCLC), specifically cT4N1M0, was identified in our patient. The second cycle of carboplatin and etoposide (CE) chemotherapy, administered four weeks beforehand, was followed by the emergence of cutaneous vasculitis and a rash, specifically affecting the lower extremities of the patient. Methylprednisolone therapy, a symptomatic treatment, replaced the CE chemotherapy regimen. Patients receiving the prescribed course of corticosteroid treatment saw an upgrade in the local conditions. Completion of chemo-radiotherapy signaled the commencement of four cycles of consolidation chemotherapy incorporating cisplatin, bringing the total number of chemotherapy cycles to six. The cutaneous vasculitis exhibited a more significant retreat, as determined by the clinical evaluation. Upon completion of the consolidation chemotherapy, elective radiotherapy for the brain was given. Until the disease returned, the patient was monitored clinically. Additional rounds of chemotherapy were given for the platinum-resistant condition. The patient's death occurred seventeen months subsequent to the SCLC diagnosis. To our knowledge, this is the initial documented instance of a patient experiencing vasculitis in their lower limbs concurrent with radiotherapy and CE chemotherapy administered as part of the initial treatment protocol for SCLC.

Traditionally, (meth)acrylates-induced allergic contact dermatitis (ACD) afflicts dentists, printers, and fiberglass workers in the occupational setting. Reports of complications associated with artificial nails have surfaced, impacting both those who apply them and those who receive them. ACD, a common consequence of (meth)acrylates used in artificial nails, is a significant concern for both nail artisans and consumers. Severe hand dermatitis, especially on the fingertips, coupled with frequent facial dermatitis, emerged in a 34-year-old woman who had been working in a nail art salon for two years. To address the frequent splitting of her nails, the patient has worn artificial nails for four months, consistently maintaining them with gel applications. Multiple episodes of asthma afflicted her while she was at her workplace. Utilizing a patch test, we evaluated the baseline series, the acrylate series, and the patient's own material.